Detectives Mike Lowrey (Will Smith) and Marcus Burnett (Martin Lawrence) return to tackle a new case that exposes a deep-rooted corruption within the Miami Police Department. The investigation takes a personal turn when they discover that their late Captain Howard (Joe Pantoliano) has been posthumously accused of acting as a mole for drug cartels over several years. Before his death, Howard leaves behind a crucial clue that sets the detectives on the path to uncovering the truth. However, their pursuit of justice quickly turns dangerous as they are framed and forced to go on the run amid a larger conspiracy. To clear their names and vindicate Howard, Mike and Marcus must operate outside the law and join forces with Mike’s estranged son, Armando Aretas (Jacob Scipio), who is currently incarcerated in a maximum-security prison following the events of the previous installment.